Prior to joining the faculty at Emory and GA Tech in Dec. 2016, Dr. Pandarinath received his bachelor’s degrees in Computer Engineering and Physics from NC State, Ph.D. in Electrical Engineering from Cornell, and was a postdoctoral fellow in Neurosurgery and Electrical Engineering at Stanford. His work has spanned systems neuroscience and brain-machine interfaces across visual and motor systems. He was the recipient of the Stanford Dean’s Fellowship and the Craig H. Neilsen Foundation Postdoctoral Fellowship in spinal cord injury research, and was a finalist for the 2015 Sammy Kuo Award in Neuroscience from the Stanford School of Medicine.
Our work centers on understanding how the brain represents information and intention, and using this knowledge to develop high-performance, robust, and practical assistive devices for people with disabilities and neurological disorders. We take a dynamical systems approach to characterizing the activity of large populations of neurons, combined with rigorous systems engineering (signal processing, machine learning, control theory, real-time system design) to advance the performance of brain-machine interfaces and neuromodulatory devices.
Jaydev P. Desai, Ph.D, is currently a Professor and BME Distinguished Faculty Fellow in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech. Prior to joining Georgia Tech in August 2016, he was a Professor in the Department of Mechanical Engineering at the University of Maryland, College Park (UMCP). He completed his undergraduate studies from the Indian Institute of Technology, Bombay, India, in 1993. He received his M.A. in Mathematics in 1997, M.S. and Ph.D. in Mechanical Engineering and Applied Mechanics in 1995 and 1998 respectively, all from the University of Pennsylvania. He was also a Post-Doctoral Fellow in the Division of Engineering and Applied Sciences at Harvard University. He is a recipient of several NIH R01 grants, NSF CAREER award, and was also the lead inventor on the “Outstanding Invention of 2007 in Physical Science Category” at the University of Maryland, College Park. He is also the recipient of the Ralph R. Teetor Educational Award. In 2011, he was an invited speaker at the National Academy of Sciences “Distinctive Voices” seminar series on the topic of “Robot-Assisted Neurosurgery” at the Beckman Center. He was also invited to attend the National Academy of Engineering’s 2011 U.S. Frontiers of Engineering Symposium. He has over 150 publications, is the founding Editor-in-Chief of the Journal of Medical Robotics Research, and Editor-in-Chief of the Encyclopedia of Medical Robotics (currently in preparation). His research interests are primarily in the area of image-guided surgical robotics, rehabilitation robotics, cancer diagnosis at the micro-scale, and rehabilitation robotics. He is a Fellow of the ASME and AIMBE.
Surgical robotics, haptics, cancer diagnosis at the micro-scale, rehabilitation robotics
Image-guided surgical robotics, rehabilitation robotics, cancer diagnosis at the micro-scale, and rehabilitation robotics.
Costas Arvanitis’ research investigates the therapeutic applications of ultrasound with an emphasis on brain cancer, and central nervous system disease and disorders. His research is focused on understanding the biological effects of ultrasound and acoustically induced microbubble oscillations (acoustic cavitation) and using them to study complex biological systems, such as the neurovascular network and the tumor microenvironment, with the goal of developing novel therapies for the treatment of cancer and central nervous system diseases and disorders.
Dr. Dixon's research focuses on elucidating and quantifying the molecular aspects that control lymphatic function as they respond to the dynamically changing mechanical environment they encounter in the body. Through the use of tissue-engineered model systems and animal models, our research is shedding light on key functions of lymphatic transport, and the consequence of disease on these functions. One such function is the lymphatic transport of dietary lipid from the intestine to the circulation. Recent evidence from our lab suggests that this process involves active uptake into lymphatics by the lymphatic endothelial cells. There are currently no efficacious cures for people suffering from lymphedema, and the molecular details connecting lymphedema severity with clinically observed obesity and lipid accumulation are unknown. Knowledge of these mechanisms will provide insight for planning treatment and prevention strategies for people facing lipid-lymphatic related diseases.
Intrinsic to the lymphatic system are the varying mechanical forces (i.e., stretch, fluid shear stress) that the vessels encounter as they seek to maintain interstitial fluid balance and promote crucial transport functions, such as lipid transport and immune cell trafficking. Thus, we are also interested in understanding the nature of these forces in both healthy and disease states, such as lymphedema, in order to probe the biological response of the lymphatic system to mechanical forces. The complexity of these questions requires the development of new tools and technologies in tissue engineering and imaging. In the context of exploring lymphatic physiology, students in Dr. Dixon's laboratory learn to weave together techniques in molecular and cell biology, biomechanics, imaging, computer programming, and image and signal processing to provide insight into the regulation of lymphatic physiology. Students in the lab also have the opportunity to work in an interdisciplinary environment, as we collaborate with clinicians, life scientists, and other engineers, thus preparing the student for a career in academia and basic science research, or a career in industry.
Systems biology, computational modeling, redox metabolism and signal tranduction.
The Kemp Lab is focused on understanding how metabolism influences the decisions that cells make. Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular fate and interpretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein network properties are influenced by redox-sensitive proteins; these proteins typically have reactive thiol groups that are post-translationally regulated in the presence of reactive oxygen species to alter activity and/or function. Experimentally, we develop novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.
To advance and to accelerate the translation of biomedical discovery, development, and delivery through comprehensive biomedical and health informatics (a.k.a. biomedical big data analytics) for personalized and predictive health care.
Director of Biocomputing and Bioinformatics Core in Emory-Georgia Tech Cancer Nanotechnology Center, and Co-Director of Georgia Tech Center for Bio-Imaging Mass Spectrometry, 3+ Years of Industrial R&D.
Integrated Biomedical Big Data Analytics and Dynamic Systems Modeling for Prediction (e.g. Molecular Pathway, Cellular System, and Whole Body Physiological System, Healthcare Systems Dynamics Modeling).
Comprehensive Biomedical and Health Informatics (e.g. Translational Bioinformatics, Microscopic Imaging Informatics, Mobile Health Informatics) for Personalized Health and Clinical Decision Support.
The work in this laboratory is focused on mechanisms underlying motor coordination in mammalian systems. These mechanisms are to be found in the structure and dynamic properties of the musculoskeletal system as well as in the organization of neuronal circuits in the central nervous system. Our work concerns the interactions between the musculoskeletal system and spinal cord that give rise to normal and abnormal movement and posture, and in the manner in which central pattern-generating networks are modified for specific motor tasks. Our studies have applications in several movement disorders, including spinal cord injury. The experimental approaches span a number of levels, from mechanical studies of isolated muscle cells to kinematic measurements of natural behavior in quadrupeds.
My laboratory studies a category of lipids, termed sphingolipids, that are important in cell structure, cell-cell communication and signal transduction. This research concerns both complex sphingolipids (sphingomyelins and glycosphingolipids) and the lipid backbones (ceramide, sphingosine, sphingosine 1-phosphate and others) that regulate diverse cell behaviors, including growth, differentiation, autophagy and programmed cell death. The major tool that we use to identify and quantify these compounds is tandem mass spectrometry, which we employ in combination with liquid chromatography for "lipidomic" analysis and in other mass spectrometry platforms (e.g., MALDI) for "tissue imaging" mass spectrometry. To assist interpretation of the mass spectrometry results, and to predict where interesting changes in sphingolipid metabolism might occur, we use tools for visualization of gene expression data in a pathway context (e.g., a "SphingoMAP"). These methods are used to characterize how sphingolipids are made, act, and turned over under both normal conditions and diseases where sphingolipids are involved, such as cancer, and where disruption of these pathways can cause disease, as occurs upon consumption of fumonisins. Since sphingolipids are also components of food, we determine how dietary sphingolipids are digested and taken up, and become part of the body's "sphingolipidome."