Diagnostic imaging and patient-specific image-guided therapeutics including cancer imaging and diagnosis.
Emelianov’s research interests are in the areas of intelligent diagnostic imaging and patient-specific image-guided therapeutics including cancer imaging and diagnosis, the detection and treatment of atherosclerosis, the development of imaging and therapeutic nanoagents, guided drug delivery and controlled release, simultaneous anatomical, functional, cellular and molecular imaging, multi-modal imaging, and image-guided therapy.
James Dahlman is an Assistant Professor in the Georgia Tech BME Department. He studied RNA design and gene editing as a post-doc with Feng Zhang at the Broad Institute, and received his PhD from MIT and Harvard Medical School in 2014, where he studied RNA delivery with Robert Langer and Daniel Anderson.
The Lab for Precision Therapies at Georgia Tech, also called the 'Dahlman Lab', works at the interface of drug delivery, nanotechnology, genomics, and gene editing. James has designed nanoparticles that deliver RNAs to the lung and heart; these nanoparticles have been used by over ten labs across the US to date. He has also developed targeted in vivo combination therapies; nanoparticles deliver multiple therapeutic RNAs at once, in order to manipulate several nodes on a single disease pathway. More recently, he developed a method to quantify the targeting, biodistribution, and pharmacokinetics of dozens to hundreds of distinct nanoparticles at once directly in vivo.
Finally, James uses molecular biology to rationally design the genetic drugs he delivers. He recently reported 'dead' guide RNAs; these engineered RNAs can be used to simultaneously up- and down-regulate different genes in a single cell using Cas9.
James has won the NSF, NDSEG, NIH OxCam, Whitaker Graduate, and LSRF Fellowships, the Weintraub Graduate Thesis Award, and was recently named a Bayer Young Investigator and Parkinson's Disease Foundation Young Investigator. He has had significant help along the way. Besides having great scientific advisors, James has been lucky to mentor excellent students, including two that were finalists for the Rhodes Scholarship.
In the Dahlman Lab, we focus on the interface between nanotechology, molecular biology, and genomics. We design drug delivery vehicles that target RNA and other nucleic acids to cells in the body. We have delivered RNAs to endothelial cells, and have treated heart disease, cancer, inflammation, pulmonary hypertension, emphysema, and even vein graft disease. Because we can deliver RNAs to blood vessels at low doses, sometimes we decide to deliver multiple therapeutic RNAs to the same cell at once. These 'multigene therapies' have been used to treat heart disease and cancer. Why is this important? Most diseases are caused by combinations of genes, not a single gene. We also rationally design the nucleic acids we want to deliver. For example, we re-engineered the Cas9 sgRNA to turn on genes, instead of turning them off. This enabled us to easily turn on gene A and turn off gene B in the same cell.
Blair Brettmann received her B.S. in Chemical Engineering at the University of Texas at Austin in 2007. She received her Master's in Chemical Engineering Practice from MIT in 2009 following internships at GlaxoSmithKline (Upper Merion, PA) and Mawana Sugar Works (Mawana, India). Blair received her Ph.D. in Chemical Engineering at MIT in 2012 working with the Novartis-MIT Center for Continuous Manufacturing under Prof. Bernhardt Trout. Her research focused on solid-state characterization and application of pharmaceutical formulations prepared by electrospinning. Following her Ph.D., Blair worked as a research engineer for Saint-Gobain Ceramics and Plastics for two years. While at Saint-Gobain she worked on polymer-based wet coatings and dispersions for various applications, including window films, glass fiber mats and architectural fabrics. Later, Blair served as a postdoctoral researcher in the Institute for Molecular Engineering at the University of Chicago with Prof. Matthew Tirrell.
Continuous pharmaceutical manufacturing, roll-to-roll coatings and films, electrospinning, polymer science, molecular engineering, surface and interfacial science, charged polymers, biomedical coatings
Blair's current research interests focus on rational design of functional advanced materials through understanding of interactions in multicomponent mixtures on the molecular scale, both at equilibrium and during processing. Her research group designs and studies new processing and characterization technologies using both experiments and theory, focusing on linking molecular to micron scale phenomena in complex systems to product performance. Application areas include pharmaceutical product development, renewable bioproducts and polymer composites.
Peng Qiu received his B.S. degree from the University of Science and Technology of China, and a Ph.D. degree from the University of Maryland College Park, both in electrical engineering. After spending three years as a postdoctoral fellow in the Center for Cancer Systems Biology at Stanford, and three years as an assistant professor in the Department of Bioinformatics and Computational Biology at UT MD Anderson Cancer Center, he joined the Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University.
Bioinformatics and computational biology, machine learning, data integration, progression analysis, single-cell analysis, flow cytometry
Bioinformatics and computational biology, machine learning, data integration, progression analysis, single-cell analysis, and flow cytometry.
My main research interests are in bioinformatics and computational biology, focusing on statistical signal processing, machine learning, control systems and optimization. The following are some specific topics that I've been working on:
Extracting the cellular hierarchy underlying high-dimensional single-cell data
Discovering Biological Progression underlying Gene Expression Data
Simultaneous classification and class discovery
Information theoretic approaches for reconstructing gene regulatory networks.
Our lab explores major questions in evolution and quantitative genetics. We work with the nematode worm C. elegans and related Caenorhabditis species. Current projects include exploring how cryptic alleles in embryogenesis depend on genetic background, how development evolves over time, and the role of molecular mechanisms in trait determination and evolution. We are also interested in how the environment influences trait expression and imposes selection in natural populations, and are conducting field collection trips in the nearby Appalachian foothills.
Cell biomechanics, systems biology, multiscale modeling and simulations, vasculogenesis, metastasis
His current research is focused on developing and applying computational methods, including mathematical modeling, simulations, and computer vision approaches to understand complex multi-scale physiological processes including vasculogenesis, morphogenesis, wound healing, and cancer.
Mechanics of materials, phase transformation and clustering, nanoscale modeling such as molecular dynamics and Monte Carlo methods, nanostructured composites, networked polymers, fracture, and drug delivery systems
Dr. Jacob's research is directed at stress induced phase changes, nanoscale characterization of materials, synthesis of polymeric nanofibers, mechanical behavior of fiber assemblies (particularly related to biological systems and biomimitic systems), nanoparticle reinforced composites, transdermal drug delivery systems, large scale deformation of rubbery (networked) polymers, and nanoscale fracture of materials. The objectives in this work, using theoretical, computational and experimental techniques, is to understand the effect of micro- and nano- structures in the behavior of materials in order to try to design the micro/nano structures for specific materials response.
Dr. Jacob plans are to continue current research interests with a multidisciplinary thrust with more emphasis in bio related areas and to start some work on the dynamic behavior of materials and structures. Graduate students could benefit from the interdisciplinary nature of the work combining classical continuum mechanics with nanoscale analysis for various applications, particularly in the nano and bio areas.
Dr. Jacob has extensive experience in vibrations and stability of structures, mechanics of polymeric materials, behavior of fiber assemblies, stress-induced phase transformation, diffusion, and molecular modeling. His research involves the application of mechanics principles, both theoretical and experimental, in the analysis and design of materials for various applications.