Our research involves synthetic and biological polymers and particles in fluids. We are particularly intrigued by disease-inspired materials research: macromolecules and biomaterials strong enough to kill an organism offer special opportunities in materials science. A great example is found in the hydrophobins, which are fungal proteins with very high surface activity. Not only do these small proteins go to surfaces, but once they arrive they form strong membranes that can stabilize sub-millimeter structures in unusual shapes. For example, hydrophobins stabilize cylindrical bubbles. This defies the principle of least surface area, and indicates that the surface-active hydrophobin proteins behave as solids once they equilibrate at the surface. We try to exploit the unusual structures. Another area of research is in synthetic polypeptides, especially when attached to particles. These materials may prove useful in chiral separations, and we believe they offer special opportunities for study of crowded colloidal suspensions. Polyelectrolyte behavior is another research theme and showcases our abilities in polymer characterization, including development of new methods.
Dr. Pardue’s lab is focused on developing treatments for people with vision loss. Steps to successful treatment require understanding the mechanisms of the disease and characterizing temporal changes to identify therapeutic windows, with the ultimate goal of rehabilitation of visual function. She uses behavioral electrophysiological, morphological, molecular, and imaging approaches to evaluate changes in retinal function and structure. Her research is guided by applying knowledge of retinal circuits and visual processing, often leading to studies of cognition and the interaction of retinal and visual circuits during health and disease. Her studies start in animal models and move to human trials when possible.
His early research efforts focused on how to use viruses to transfer genes to cells for the purpose of human gene therapy. More recently, he has shifted his research to the learning sciences, focusing on understanding how the generation of engineering diagrams is used to support problem-solving, both by novice and expert engineers.
In the Whiteley Lab, we are interested in the social lives of bacteria. Currently, we are utilizing new technologies combined with classical genetic techniques to address questions about microbial physiology, ecology, virulence, and evolution. In particular, we are working on tackling the following questions:
1. How do bacteria communicate?
2. How do polymicrobial interactions impact physiology and virulence?
3. What is the role of spatial structure in bacterial infections?
4. How does the host environment impact microbial physiology?
We are interested in how ecology and evolution shapes cooperation, cheating and signaling (quorum sensing) in microbial populations, and the implications of this for the evolution of virulence and antibiotic resistance during infection. Our emphasis is on chronic infections such as those found in cystic fibrosis lungs, diabetic ulcers and non-healing wounds.
Professor James Rains is a faculty member of the Wallace H. Coulter Department of Biomedical Engineering. He has 13 years of product development experience working for industry leaders Stryker and Smith&Nephew. Professor Rains has ten issued patents and readily works with industry professionals and clinicians to solve healthcare issues.
Design, medical device development, and entrepreneurship.
Work with physicians and industry to develop solutions to unmet clinical needs. If you have a problem that needs to be addressed, we can help you solve it.
Predictive medicine, health informatics, data analytics, modeling, biocuration, neuropathology, neuroengineering
Cassie Mitchell’s research goal centers around expediting clinical translation from bench to bedside using data-enabled prediction. Akin to data-based models used to forecast weather, Cassie’s research integrates disparate, multi-scalar experimental and clinical data sets to dynamically forecast disease. Cassie is the principal investigator of the Laboratory for Pathology Dynamics, which uses a combination of computational, analytical, and informatics-based techniques to identify complex disease etiology, predict new therapeutics, and optimize current interventions. Cassie’s research has predominantly targeted neuropathology, but her research applications in predictive medicine expand across all clinical specialties.