We develop spectroscopic coherent Raman microscopy methods and apply them to biological, biotechnology, and biomedical problems. We are currently working on improving speed, precision, and simplicity of broadband coherent Raman scattering (BCARS) microscopy techniques. On the biology side, we are applying these coherent Raman microscopy techniques to understand mechanism of viral replication in human cells, and lipid metabolism in C. elegans, and to characterize cell phenotype for cell manufacturing applications. On the biomaterials and pharmaceutics side, we use coherent Raman imaging to map chemical distributions and interactions. Here we also use a Raman-derived readout of THz-range dynamic processes to predict rates of reaction and degradation in condensed matter systems.
Our study focuses on Soft Active Materials especially those consisting both solid and liquid, such as gels, cells and soft biological tissues. Our research is at the interface between mechanics and materials chemistry. Our studies span from fundamental mechanics to novel applications.
Computational Ophthalmology, Machine Learning, Image/Video Processing, Computer Vision, Perception, Scene Understanding, Seismic Interpretation, Learning in the Wild, Learning for Autonomous Vehicles, Medical Image Analysis,