John McDonald




Primary School/Department: 
School of Biological Sciences
Title 2: 
Director, Integrated Cancer Research Center
Title 3: 
Chief Scientific Officer, Ovarian Cancer Institute

Office Location: 
IBB 3314
Georgia Institute of Technology

Research Affiliations:

Research Center Affiliations: 
Center for Bio-Imaging Mass Spectrometry
Integrated Cancer Research Center
Center for Drug Design Development & Delivery

Research Areas:

Research Areas: 
Cancer Biology
Drug Design, Development and Delivery
Systems Biology

Research Interests:

In the McDonald lab, we are taking an integrated systems approach to the study of cancer. This means that we view cancer not as a defect in any particular gene or protein, but as a de-regulated cellular/inter-cellular process. An understanding of such complex processes requires the implementation of experimental approaches that can provide an integrative holistic or 'systems' view of intra-and inter-cellular process. We employ a number high-throughput genomic (e.g., DNA-seq, RNA-seq, microarray) technologies to gather systems data on the status of cancer cells. We strive to integrate into our research program, the exceptional strengths that exist at Georgia Tech in the fields of engineering and the computational sciences.
Our current goals are:
1) development of a generalized cancer diagnostic using mass spectrometric metabolic profiling;
2) development of small non-encoding RNAs as potential therapeutic agents and the use of functionalized nanoparticles (nanohydrogels) for their targeted delivery to cancer cells; and
3) exploring the significance of mRNA splice variants in the onset and progression of cancer.