Dr. Arbiser's research focuses on the regulation of angiogenesis and tumorigenesis by signal transduction pathways. Our laboratory has chosen three model systems to study these relationships. The first area is the common vascular birthmarks of children and their malignant counterparts, angiosarcomas. The second application of these studies are benign neoplasms which develop in the autosomal dominant syndrome tuberous sclerosis (TS). The third application of these studies is in the pathogenesis of malignant melanoma. Dr Arbiser has developed the hypothesis that oncogenes disrupt the balance between angiogenesis stimulators and inhibitors.