Christopher C. Porter, MD

Christopher Porter MD




Associate Professor|Pediatrics
Primary School/Department: 
Emory+Children's Pediatric Research Center

Office Location: 
HSRB, Emory University
Emory University

Research Keywords:

childhood cancer, leukemia, cancer predisposition, cancer immunology

Research Areas:

Research Areas: 
Cancer Biology

Research Interests:

The goal of the Porter lab is to develop novel therapeutic strategies for leukemia through better understanding of molecular mechanisms of leukemogenesis and treatment resistance. We employ a wide variety of techniques, in vitro and in vivo, for discovery and validation of molecular vulnerabilities in cancer cells. For example, using a genome-scale shRNA screen, we identified WEE1 as a chemosensitizing target in AML cells. Subsequent studies funded by the NCI have validated this finding and supported the development of a clinical trial testing a WEE1 inhibitor in children with relapsed/refractory AML. More recently, we have discovered a novel function for the transcription factor ETV6 in regulating normal B cell development, and will test whether and how Etv6 mutation promotes leukemogenesis using a new mouse model with a point mutation in Etv6. A third project in the lab is directed at understanding mechanisms of immune evasion during leukemogenesis.