Wendell Lim, Ph.D.
Professor of Cellular and Molecular Pharmacology
Biochemistry and Biophysics and Pharmaceutical Chemistry
Investigator, Howard Hughes Medical Institute
Byers Distinguished Professorship
University of California San Francisco
My laboratory is interested in the logic of cell signaling systems: understanding how the networks of signaling proteins found in eukaryotic cells have evolved to allow cells to make complex behavioral decisions. We use two broad approaches to attack this problem. First we use biochemistry, cell biology, genetics, and computational biology to dissect the mechanisms of signaling proteins and networks. We are particularly interested in understanding how nature’s toolkit of modular domains are recombined through evolution to generate new and diverse response behaviors. Second, we use synthetic biology: the redesign of biological systems. In particular, we are using various methods to create novel or modified signaling proteins and pathways, both to systematically understand network structure/function relationships and to develop engineered research tools and novel biotechnological and therapeutic applications.
A community lunch will be served immediately following the presentation.