Catherine Klapperich, Ph.D.
Department of Radiology
We work to deliver healthcare in limited resource settings and to limit the use of resources in all settings.
Many new and exciting portable molecular testing technologies are emerging for application in both personalized and global medicine. The potential to provide fast, isothermal, and quantitative molecular diagnostic information to clinicians in the field and at the bedside will soon be a reality. What many of these technologies lack is a robust front end for sample clean up and nucleic acid preparation. Such technologies would enable many different downstream molecular assays.
The Klapperich Laboratory is focused on the design and engineering of manufacturable, disposable systems for low-cost point-of-care molecular diagnostics. We have invented technologies to perform microfluidic sample preparation for bacterial and viral targets from several human body fluids including, urine, blood, stool and nasowash. These technologies include nucleic acid extraction, microorganism and small molecule enrichment and/or concentration and small-scale dialysis. We are currently working on devices for the detection and quantification of HIV, sexually transmitted infections, drug adherence, and continuous physiological monitoring.
Projects include detection by PCR, isothermal amplification, and novel optical techniques. Our main application area is global health. We consider assay development, device design, sample flow, storage and transport all opportunities to drive down the cost and increase the accessibility of molecular tests in the developing world.
The Bioengineering Seminar Series is co-hosted by the Parker H. Petit Institute for Bioengineering and Bioscience, and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.